In order to optimize the process of polyphenols by macroporous resin from Empetrum nigrum aerial parts， moisture content， adsorption rate and desorption rate of six resins（HPD-100， X-5， AB-8， D101， HPD-600 and NKA-Ⅱ） were investigated， and the resin with the best effect was selected. Four factors（sample concentration， ethanol concentration， elution flow rate and elution volume） that have a great influence on the purification process were selected， and the response surface method was used to analyze the optimal process. HPD-600 macroporous resin had the best purification effect on polyphenols yield. The optimal extraction conditions were as follows： sample concentration was 0.84 mg·mL-1， ethanol concentration was 62.15%， elution flow rate was 0.67 mL·min-1， and elution volume was 2.71 BV. Under these conditions， the yield of polyphenols was 229.18 mg·g-1， the purity of polyphenols was increased from 8.11% to 22.56%， and the recovery rate was 67.78%.
%U https://bbr.nefu.edu.cn/EN/10.7525/j.issn.1673-5102.2021.04.018