%0 Journal Article
%A *
%A FU Yu-Jie
%A LI Shuang-Ming
%A LI Zheng-Nan
%A LUO Hao
%A MA Yong-Ting
%T Optimization of Synthesis Process of Isoliquiritigenin
%D 2009
%R 10.7525/j.issn.1673-5102.2009.05.024
%J Bulletin of Botanical Research
%P 637-640
%V 29
%N 5
%X Isoliquiritigenin was synthesized with 2,4-Dihydroxyacetophenone and 4Hydroxybenzaldehyde as the starting materials by protecting of hydroxy, Aldol Addition and deprotecting. The reaction conditions of the key step-Aldol Addition, including catalyst, ratio of substrates, temperature, solvent and time were optimized. Results showed that the optimal condition of the key step were as follows: catalyst Ba(OH)<sub>2</sub>, solvent MeOH, M(4-Hydroxybenzaldehyde):M(2,4-Dihydroxyacetophenone)=1.8∶1, tempetature 45℃, and time 12 h. Under the optimal conditions, the yield of the reaction achieved the highest(77.9%). In addition, the reaction system was simple and easily purified.
%U https://bbr.nefu.edu.cn/EN/10.7525/j.issn.1673-5102.2009.05.024